Science

    New Strain Of Lactic Acid Bacterium Could Be Promising Probiotic For Food And Pharmaceutical Industry

    New Strain Of Lactic Acid Bacterium
    Inam Ansari
    July22/ 2024

    New Delhi (The Hawk): Scientists have uncovered a new strain of lactic acid bacterium that could be a promising candidate for broader probiotic utilization beyond the dairy industry. The researchers from Agharkar Research Institute (ARI) Pune, an autonomous institute of the Department of Science and Technology were keen to uncover the hidden potential of S. thermophilus often acclaimed for its role as a starter culture in various dairy products, through a collaborative genome analysis. A probe into the genetic makeup of strain MCC0200 revealed an arsenal of genes associated with gastrointestinal survival, intestinal adhesion, and health-promoting functionalities, painting a vivid picture of its probiotic prowess. One of the key challenges for any probiotic is surviving the treacherous journey through the human digestive system. In vitro studies revealed that MCC0200 not only withstands the harsh conditions of the gastrointestinal tract but also exhibits remarkable resilience against gastric juices and bile acids, which are the known crucial factors in determining probiotic efficacy. Delving deeper into its genome, the study published in the journal Microorganisms uncovered a repertoire of genes that can help acid tolerance and bile resistance, shedding light on the molecular mechanisms underpinning its survival strategy. They found that MCC0200 which thrives in the gut, possesses a strong affinity for intestinal surfaces, allowing it to interact with host cells. This ability to adhere to mucosal surfaces is a crucial factor in promoting gut health and immune function. They also unravelled MCC0200's ability to auto aggregate and co-aggregate with pathogenic bacteria, a trait essential for competitive exclusion and gut colonization. Stud ...

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