Finland (Europe): Menopausal transition increases women's body fat, especially around the waist, according to a study conducted at the University of Jyvaskyla's, Finland. As a result, women in their forties and fifties are advised to pay special attention to good lifestyle habits--physical activity and a healthy diet--to help alleviate the health risks associated with fat accumulation.The study was published in the journal, 'Aging Cell'. In the period of life prior to and after menopause, women tend to accumulate more fat in their bodies; the distribution of fat in the different regions of the body changes as well. Before menopause, women typically have more fat in their thigh and gluteal areas compared to men, but in midlife, many women notice an increase in fat, especially in their waist area. In addition to the total amount, the location of this adipose tissue also is meaningful to one's overall health, especially because mid-region fat has been shown to increase the risk for cardiovascular disease and type 2 diabetes. "Aging increases total body adipose tissue accumulation in both men and women, but it seems that menopause may accelerate these changes in women," says doctoral researcher Hanna-Kaarina Juppi. "Although several studies have been conducted on this issue, the role of menopause specifically in the changing fat distribution is still under debate. Since women typically live in the postmenopausal state for several decades, it is crucial to study these changes and understand their meaning to health."In the current study, middle-aged women approaching menopause were followed for a maximum of 4 years over the menopausal transition. At the beginning and end of the study, women's body composition, mid-thigh adipose tissue area, and adipose-tissue-derived hormones from their blood were measured. Information was collected also regarding the level of physical activity, diet, and the use of hormone therapy. Fat accumulation was investigated also at the muscle fibre level. During the follow-ups, researchers found an increase in the fat mass over the entire body, with a notable increase in the waist area. Women who were more physically active and partook in a healthier diet during the study had lower fat mass. The use of hormone preparations was not associated with body fatness."The results indicate that menopause affects body fat accumulation in women. Contrary to expectations, the increase in the amount of adipose tissue of our participants had only moderately negative effects on the hormones derived from the adipose tissue that reflect metabolic health," Juppi continues. "We suspect that the relatively healthy lifestyle habits of our participants helped them sustain metabolic health despite an increase in fat mass and menopause."Conducted at the Gerontology Research Center in the Faculty of Sport and Health Sciences at the University of Jyvaskyla, this research is part of the Estrogenic Regulation of Muscle Apoptosis (ERMA) and Estrogen, MicroRNAs and the Risk of Metabolic Dysfunction (EsmiRs) studies led by Associate Professor Eija Laakkonen. Nearly 1,400 Finnish women aged 47 to 55 years old participated in the original ERMA baseline. Of them, 230 women participated in the ERMA and 148 in the EsmirS follow-up studies. The research has been funded by the Academy of Finland.&nbsp;—ANI

Menopausal transition increases women's body fat, especially around the waist, according to a study conducted at the University of Jyvaskyla's, Finland. As a result, women in their forties and fifties are advised to pay special attention to good lifestyle habits--physical activity and a healthy diet--to help alleviate the health risks associated with fat accumulation.

Physical Activity, Healthy Diet Can Help Protect You From Health Risks During Menopause

Lucknow: Uttar Pradesh deputy chief minister Brajesh Pathak has said that the state government was focusing on ease of doing business, along with maintaining good law and order.He said that the government is working and taking necessary steps to attract investment and boost employment opportunities in the state, especially in the Micro, Small and Medium Enterprises (MSMEs) sector. Pathak was speaking at a two-day conference, organised by the Associated Chambers of Commerce and Industry of India (ASSOCHAM) in association with the Ministry of MSME, Union Government.The conference, which aims to develop cottage and small-scale industries and improve their competitiveness, is being organised at a time when the country is celebrating the Amrit Mahotsav of Independence.The deputy chief minister assured all possible help to the industry body in its efforts to increase investment in the state and lauded ASSOCHAM for organising this conference, in which entrepreneurs from within the country and around the world are participating, in Lucknow.He said that his government first focused on improving law and order to create a better environment for investors in the state.Entrepreneurs, who used to shy away from investing in Uttar Pradesh, have started investing in the state after the situation improved. Apart from having skilled manpower available, there is also a huge market. The deputy chief minister added that the government has introduced a single-window system for the convenience of entrepreneurs so that all types of approvals can be given to them at one place. For speedy settlement of commercial disputes, the state government has opened 13 new commercial courts in the last five years.He said that the MSME sector contributes close to 50 per cent of the country's export sector. At the same time, this sector accounts for about 30 per cent of the country's GDP. In such a situation, the role of MSMEs becomes crucial in making India a stronger position in global trade. —IANS

Uttar Pradesh deputy chief minister Brajesh Pathak has said that the state government was focusing on ease of doing business, along with maintaining good law and order.

UP Govt's Focus On Ease Of Doing Business, Good Law And Order: Pathak

Chennai (The Hawk): The critical cryogenic engine of its rocket LVM3 is being tested by the Indian space agency as it prepares to launch the next set of 36 satellites of the UK-based Network Access Associated Ltd (OneWeb) in January 2023.
The flight acceptance hot test of a CE-20 engine was successfully completed for a period of 25 seconds in the High Altitude Test facility of ISRO Propulsion Complex at Mahendragiri, according to the Indian Space Research Organisation (ISRO).
According to ISRO, this engine is designated for the LVM3-M3 mission, which will launch the following 36 OneWeb India-1 satellites.
The cryogenic upper stage (C25 stage) of the LVM3 spacecraft is propelled by a CE-20 engine that uses a combination of liquid oxygen and liquid hydrogen (LOX-LH2) propellants.
In vacuum, this engine produces a nominal thrust of 186.36 kN.
The main goals of the flight acceptance test were to verify the hardware's integrity, evaluate the performance of the subsystems, and tune the engine to comply with the mission criteria for engine tuning for fly operation.
The engine systems' acceptable performance was validated by an analysis of the test data.
This engine will be put together and fitted into the LVM3 M3 rocket's C25 launch stage.
According to Sunil Bharti Mittal, chairman of OneWeb, ISRO's commercial branch NewSpace India Ltd (NSIL) has signed an agreement with the company to launch 72 satellites in two phases for a cost exceeding Rs 1,000 crore.
On October 23 from the Sriharikota rocket port in Andhra Pradesh, the LVM3 rocket, also known as the Geosynchronous Satellite Launch Vehicle MkIII, successfully orbited the first set of 36 satellites (GSLV MkIII).
To provide its broadband services globally, OneWeb proposes to build a constellation of 648 satellites in low earth orbit (LEO).
(Inputs from Agencies)

The critical cryogenic engine of its rocket LVM3 is being tested by the Indian space agency as it prepares to launch the next set of 36 satellites of the UK-based Network Access Associated Ltd (OneWeb) in January 2023.

ISRO preparing for Jan 2023 OneWeb satellite launch

Texas: Stroke is a significant risk factor for dementia, severe long-term impairment, and mortality. According to the American Heart Association, depression is more common in stroke patients, which has an adverse influence on the recovery of cognitive and functional abilities.
The Texas A&amp;M team investigated the novel idea of whether transplant of intestinal epithelial stem cells (IESCs) from healthy donors could repair the intestinal barrier after stroke and improve stroke outcomes. Results from their preclinical study, published in the journal Brain, Behavior, and Immunity, indicate that IESC transplantation reduced stroke-induced mortality, decreased the volume of dead tissue and gut leakiness, and prevented stroke-induced cognitive impairment.
The only recombinant tissue plasminogen activator licenced by the Food and Drug Administration (FDA) for the treatment of strokes has a limited track record and must be administered quickly after the onset of the stroke. Researchers at the Texas A&amp;M University School of Medicine are leading research on the relationship between stroke-induced intestinal permeability, or leakiness, and cognitive impairment with the goal of improving stroke outcomes.
Two-thirds of stroke patients will develop cognitive impairment, while one-third of all stroke patients will go on to develop dementia, according to recent research, so there is a critical need for more effective stroke therapies that preserve cognitive function after acute stroke and that remain protective in the weeks following.
Although conventional stroke treatment research focuses on the brain, the gut responds early and rapidly to stroke with changes that may precede many of the inflammatory events associated with stroke-induced disease. These changes in the gut, such as increased permeability, likely result in the movement of products that are synthesized in the gut into the blood stream. Many of these products are toxic and therefore in a position to increase inflammation and exacerbate stroke-induced brain injury.
Evidence from a variety of studies demonstrates that IESCs repair the gut and reduce gut permeability. After a stroke, these repair processes may be critical to preserving cognitive function.
"It is clear that the gut-brain axis is involved in injury following stroke," said Farida Sohrabji, PhD, Regents Professor, department head for Neuroscience and Experimental Therapeutics and senior author of the study. "Factoring in the effects of gut health on the brain following stroke may allow us to more effectively advance stroke therapies."
With that in mind, Sohrabji and her team transplanted primary IESCs from healthy donors after stroke in a preclinical model. IESCs from young donors repaired gut architecture and decreased gut permeability and consequently decreasing blood levels of proteins and other molecules that are toxic to brain cells. IESC transplantation also prevented depressive-like behaviors and cognitive impairment in the weeks following the stroke. IESC transplantation from older donors did not improve stroke outcomes, indicating that successful transplantation depends on the age of the donor.
Still at the preclinical stage, this research highlights the importance of early therapeutic intervention after stroke and will guide future directions of the work. "Future studies will investigate refinement of the dosing and timing of the protocol," Sohrabji said. "A systematic study of aging stem cells would also be important to explain why older patients experience more severe strokes."
Sohrabji, a neuroscientist with significant contributions to the literature on stroke pathogenesis, explained that this preclinical study was spearheaded by Kathiresh Kumar Mani, PhD, an associate research scientist in her lab. Mani, who is trained in gut biology, received a postdoctoral grant from the American Heart Association in support of this project. Combining their expertise has allowed them to move stroke therapy research into new territory with exciting results. They also received a generous grant from the WoodNext Foundation that is facilitating their innovative research.
"Ultimately, this research is expected to advance development of novel therapies that target and repair the intestinal epithelium to help mitigate stroke disability," Sohrabji said, "but the premise--that gut stem cells might be therapeutically valuable outside of the gut--could be considered for a much greater variety of neurological diseases." —ANI

Stroke is a significant risk factor for dementia, severe long-term impairment, and mortality. According to the American Heart Association, depression is more common in stroke patients, which has an adverse influence on the recovery of cognitive and functional abilities.

The Hawk

Tag : Associated

Physical Activity, Healthy Diet Can Help Protect You From Health Risks During Menopause

Inam Ansari

The Hawk

Tag : Associated

Physical Activity, Healthy Diet Can Help Protect You From Health Risks During Menopause

Inam Ansari

More about Associated

UP Govt's Focus On Ease Of Doing Business, Good Law ...

ISRO preparing for Jan 2023 OneWeb satellite launch

Study Finds How Gut, Stroke-Induced Cognitive Impair ...